Cynata Therapeutics Limited ABN – 98 104 037 372 Level 3, 100 Cubitt Street Cremorne, VIC 3121 Australia T: +613 7067 6940 E: info@cynata.com www.cynata.com 16 October 2026 Dear Shareholder Cynata Therapeutics Limited – Pro-Rata Renounceable Entitlement Offer On behalf of the Directors of Cynata Therapeutics Limited (ACN 104 037 372) (CYP or the Company), and in accordance with the terms of the entitlement offer replacement prospectus (Prospectus) lodged with ASIC and ASX on 12 October 2026, I am pleased to invite Eligible Shareholders to participate in a fully underwritten pro rata renounceable entitlement offer (Entitlement Offer). Other than as defined in this letter, capitalised terms have the meanings given to them in the Prospectus. The Entitlement Offer, which is fully underwritten by Caravel Securities Pty Ltd, aims to raise approximately $913,000 (before costs) and has the following terms: 1. The Entitlement Offer is renounceable and pro-rata to Eligible Shareholders on the basis of three (3) fully paid ordinary shares in the capital of the Company (New Shares) for every eight (8) Shares held by those Shareholders at the Record Date of 13 October 2026 at an Offer Price of $0.01 per New Share. 2. For every three (3) New Shares subscribed for under the Entitlement Offer, Eligible Shareholders will receive one (1) free attaching option (Option), on the following terms: a. Option exercise price of $0.02; and b. Option expiry date 2.5 years after the date of issue. The funds raised from the Entitlement Offer will be used to pay for professional advisers, Director and consultant fees in furtherance of the Company’s strategic objectives and to pay for the costs of the Offers and for working capital purposes. Thank you for your support of Cynata. Further details regarding the Entitlement Offer are provided below and in the Prospectus. Yours sincerely Dr Geoffrey Brooke Non-Executive Chair Participation in the Entitlement Offer The Entitlement Offer is being made to all Shareholders of the Company named on its register of members at 7:00pm (AEDT) on 13 October 2026, whose registered address is in Australia, New Zealand or Singapore (Eligible Shareholders). Participation in the Offer You have been deemed to be an Eligible Shareholder for the purposes of the Entitlement Offer. The Entitlement Offer opens on 16 October 2026 and is expected to close at 5:00pm (AEDT) on Tuesday, 27 October 2026 (unless extended) as set out in the Prospectus. The number of New Shares for which you are entitled to apply for under the Entitlement Offer is shown on your personalised Entitlement and Acceptance Form, which, along with the Prospectus, is accessible at one of three links on the following page. You are not permitted to subscribe for New Shares in excess of your Entitlement. If you wish to participate in the Entitlement Offer, please follow the instructions contained in the Entitlement and Acceptance Form and below. If you have any queries regarding the Entitlement Offer or require a hard copy of the Prospectus, please contact your stockbroker, accountant, other independent professional adviser or the Company's registry, Automic Registry Services on 1300 288 664 (callers within Australia) or +61 2 9698 5414 (callers outside Australia) at any time between 8:30 am to 7:00 pm (AEDT) Monday to Friday, up to the Closing Date of the Offer. How to access the Entitlement Offer 1. Online – The Prospectus and your personalised Entitlement and Acceptance Form can be accessed via the Automic Investor Portal at: https://portal.automic.com.au/investor/home. 2. Paper – Request a copy of the Prospectus and your personalised Entitlement and Acceptance Form by contacting Automic on 1300 288 664 or +61 2 9698 5414, or by email at corporate.actions@automicgroup.com.au. To download the Prospectus and your personalised Entitlement and Acceptance Form, you may use one of the following methods: I already have an Automic Investor Portal login I do not have an Automic Investor Portal login and wish to register I do not have an Automic Investor Portal login but wish to access this Entitlement Offer only • Access the Automic Investor Portal at: https://portal.automic.com.au /investor/home • Select "Existing Users Sign In" and log in to your account. • Navigate to “Documents and Statements”. • Download the Prospectus and your Entitlement and Acceptance Form. • Register via: https://singleholding.automic. com.au/signup • Select “Cynata Therapeutics Limited” from the Issuer dropdown. • Enter your SRN/HIN (from your latest holding statement). • Enter a single identifying word from your holder name. • Enter your postcode (Australia) • Register via: https://singleholding.automic. com.au/login • Select “Cynata Therapeutics Limited” from the Issuer dropdown. • Enter your SRN/HIN (from your latest holding statement). • Enter a single identifying word from your holder name. I already have an Automic Investor Portal login I do not have an Automic Investor Portal login and wish to register I do not have an Automic Investor Portal login but wish to access this Entitlement Offer only • Submit your Application by making payment in accordance with the personalised payment instructions on your Entitlement and Acceptance Form. Do not return your Entitlement and Acceptance Form. or country of residence (overseas). • Complete the verification and follow the prompts to register. Once registered: • Log in and go to “Documents and Statements”. • Download the Prospectus and your Entitlement and Acceptance Form. • Submit your Application by making payment in accordance with the personalised payment instructions on your Entitlement and Acceptance Form. Do not return your Entitlement and Acceptance Form. • Enter your postcode (Australia) or country of residence (overseas). • Complete the verification and follow the prompts. Once logged in: • Navigate to “Documents and Statements”. • Download the Prospectus and your Entitlement and Acceptance Form. • Submit your Application by making payment in accordance with the personalised payment instructions on your Entitlement and Acceptance Form. Do not return your Entitlement and Acceptance Form. Elect to receive communications electronically You have received this letter by post because you have not nominated an email address or elected to receive shareholder communications electronically. The Company encourages all shareholders to receive communications electronically, which provides timely access to important shareholder information. To update your communication preferences, please scan the QR code or visit https://portal.automic.com.au/investor/home and follow the instructions to register or update your details. The Entitlement Offer closes at 5:00pm (AEDT) on 27 October 2026 (unless extended). Key dates for the Offers Action Date Original Prospectus lodged with ASIC and ASX and Appendix 3B lodged with ASX Thursday, 8 October 2026 Ex-date for Entitlement Offer Entitlement trading commences on a deferred settlement basis Lodgement of replacement Prospectus with ASIC and ASX Monday, 12 October 2026 Record Date for eligibility to participate in the Entitlement Offer Tuesday, 13 October 2026 Offer Opening Date Friday, 16 October 2026 Prospectus & Entitlement & Acceptance Form available to Eligible Shareholders Underwriter Option Offer opens Entitlement trading ends at ASX market close Tuesday, 20 October 2026 Offer Closing Date Tuesday, 27 October 2026 Action Date Entitlement Offer and Underwriter Option Offer close Announcement of results of the Entitlement Offer Friday, 30 October 2026 Issue of New Shares & Entitlement Options under the Entitlement Offer & Underwriter Option Offer Tuesday, 3 November 2026 Trading of New Shares issued under the Entitlement Offer Wednesday, 4 November 2026 Despatch of holding statements for New Shares & Options Wednesday, 4 November 2026 * Cynata reserves the right to vary these times and dates, by agreement with the Underwriter. All times are Melbourne times. Additional information If you have any questions regarding the Entitlement Offer or require assistance accessing the Prospectus or your personalised Entitlement and Acceptance Form, please contact the Company's share registry Automic by email at corporate.actions@automicgroup.com.au or by phone on 1300 288 664 (within Australia) or +61 2 9698 5414 (outside Australia). You should read the Prospectus in its entirety and consider seeking professional advice before making any investment decision in relation to the Entitlement Offer. For other questions, you should consult your broker, solicitor, accountant, financial adviser or other professional adviser.