Announcement PDF ASX ANNOUNCEMENT 31 May 2023 Section 708A(5)(e) Notice – Issue of Cynata Therapeutics Limited shares without a prospectus Melbourne, Australia; 31 May 2023: Cynata Therapeutics Limited (ASX: “CYP” or “Cynata”) has today issued 640,694 fully paid ordinary shares in the Company (Shares) in connection with the Director Placement component of the capital raising which was announced to ASX on 6 April 2023 (Capital Raising). The Company’s shareholders approved the Director Placement at a general meeting held on 25 May 2023. The 18,177,637 options to be issued in connection with the Capital Raising will be issued on 1 June 2023 and will be quoted on ASX under the code CYPOA. The Company gives notice under section 708A(5)(e) of the Corporations Act 2001 (Cth) (Act) that: 1. the Company issued 640,694 Shares without disclosure to investors under Part 6D.2 of the Act; 2. as at the date of this notice, the Company has complied with: (a) the provisions of Chapter 2M of the Act as they apply to the Company; and (b) sections 674 and 674A of the Act; and 3. as at the date of this notice, there is no information that is ‘excluded information’ (within the meaning of section 708A(7) and section 708A(8) of the Act). -ENDSAuthorised for release by Dr Ross Macdonald, Managing Director & CEO CONTACTS: Dr Ross Macdonald, CEO, Cynata Therapeutics, +61 (0)412 119 343, ross.macdonald@cynata.com Lauren Nowak, Media Contact, +61 (0)400 434 299, littlebigdealconsulting@gmail.com About Cynata Therapeutics (ASX: CYP) Cynata Therapeutics Limited (ASX: CYP) is an Australian clinical-stage stem cell and regenerative medicine company focused on the development of therapies based on Cymerus™, a proprietary therapeutic stem cell platform technology. Cymerus™ overcomes the challenges of other production methods by using induced pluripotent stem cells (iPSCs) and a precursor cell known as mesenchymoangioblast (MCA) to achieve economic manufacture of cell therapy products, including mesenchymal stem cells (MSCs), at commercial scale without the limitation of multiple donors. Cynata’s lead product candidate CYP-001 met all clinical endpoints and demonstrated positive safety and efficacy data for the treatment of steroid-resistant acute graft-versus-host disease (GvHD) in a Phase 1 trial. Planning for a Phase 2 clinical trial in GvHD under a cleared US FDA IND is presently underway. Clinical trials of Cymerus products in osteoarthritis (Phase 3) and diabetic foot ulcers (DFU) are currently ongoing. In addition, Cynata has demonstrated utility of its Cymerus technology in preclinical models of numerous diseases, including the clinical targets mentioned above, as well as critical limb ischaemia, idiopathic pulmonary fibrosis, asthma, heart attack, sepsis, acute respiratory distress syndrome (ARDS) and cytokine release syndrome. Cynata Therapeutics encourages all current investors to go paperless by registering their details with the designated registry service provider, Automic Group. Cynata Therapeutics Limited Level 3, 100 Cubitt Street, Cremorne, Victoria, 3121, Australia PO Box 7165, Hawthorn North, Victoria 3122 T: +613 7067 6940 E: info@cynata.com ABN – 98 104 037 372