Announcement PDF Cynata Therapeutics Limited ABN – 98 104 037 372 Level 3, 100 Cubitt Street Cremorne VIC 3121 Australia T: +613 7067 6940 E: info@cynata.com www.cynata.com ASX ANNOUNCEMENT 20 October 2026 Unmarketable Parcel Sale Facility Cynata Therapeutics Limited (Cynata or the Company) (ASX: CYP) is pleased to announce that it has established a Share Sale Facility for holders of Unmarketable Parcels of shares in the Company (Facility). An ‘Unmarketable Parcel’ is a parcel of shares with a market value of less than A$500. As at market close on 19 October 2026 (Record Date), an Unmarketable Parcel of ordinary shares in the Company (Shares) is any shareholding of 49,999 Shares or less, based on the closing price on ASX of $0.01 per Share. As of the Record Date, Unmarketable Parcels comprise approximately 19,228,197 Shares (7.9% of Cynata’s issued Shares), held by approximately 2,363 shareholders. The Company is providing the Facility to holders of Unmarketable Parcels to sell their Shares without incurring any brokerage or handling costs that could otherwise make a sale of their Shares uneconomic or difficult. The Company values its shareholders and by making this Facility available, the Company expects to reduce the administrative costs associated with maintaining a number of small holdings. Shareholders with an Unmarketable Parcel who wish to take advantage of the Facility and have their Shares sold do not need to take any action. Shareholders will have the ability to retain their Unmarketable Parcel of Shares by returning the Share Retention Form or submitting an online retention election on or before 7.00pm Melbourne time on Monday, 7 December 2026, otherwise their Shares will be sold by the Company through the Facility. Caravel Securities Pty Ltd ACN 665 357 915 (Carasec) has been appointed as broker to seek to sell the Shares sold under the Facility. Sale proceeds will be forwarded to participating shareholders as soon as practicable following settlement. All costs and brokerage fees will be paid by the Company, excluding any tax consequences, which will remain the responsibility of shareholders. There is no guarantee that Carasec will be able to sell any or all of the Shares offered for sale under the Facility. Shares sold under the Facility will be sold at a price of $0.01 per Share, which is the same price as Shares are being offered under the Company’s recently announced Entitlement Offer (refer to Prospectus of 12 October 2026 available at www.asx.com.au). The Shares will be placed as a single pooled parcel for sale by Carasec and all shareholders who sell their Shares through the Facility will receive the same price per Share, with no deduction for brokerage or handling costs. A summary of the key dates in relation to the Facility is as follows: Event Date Unmarketable Parcels Record Date Monday, 19 October 2026 Unmarketable Parcels Announcement to ASX Tuesday, 20 October 2026 Letters sent to shareholders holding Unmarketable Parcels Friday, 23 October 2026 Closing Date for receipt of Share Retention Form Monday, 7 December 2026 Sale of Shares and payment of proceeds Late December 2026 Subject to its Constitution and the ASX Listing Rules, the Company reserves the right to change any of the dates referred to in this announcement or the enclosed letter or Share Retention Form, or to vary, cancel or delay the Facility at any time before the Shares are sold, by making an announcement to ASX. The Company does not provide any recommendation or advice as to whether shareholders holding an Unmarketable Parcel should sell or retain their shares. Shareholders may also wish to obtain tax advice regarding the implications of participating in the Facility. Attached is a copy of the letter, fact sheet and Share Retention Form which will be despatched to all shareholders holding an Unmarketable Parcel of Shares as at the Record Date. If you have any questions about the Facility, please contact the Company on +613 7067 6940 or via email at info@cynata.com. ENDS- Authorised for release by the Board of Directors CONTACT: investors@cynata.com About Cynata Therapeutics (ASX: CYP) CynataTherapeuticsLimited’s (ASX:CYP) core assetis currentlythe Cymerus™ platform, which offersagenuinelydifferentiated approach to manufacturing mesenchymal stromal cells at commercial scale from a single, consistent cell source. The Board is now focused on evaluating the future development pathways available for this technology, and the broader strategic options open to the Company. This includes seeking opportunities to realise value from the Cymerus™ technology and obtaining rights to new assets. Cynata Therapeutics encourages all current investors to go paperless by registering their details with the designated registry service provider, Automic Pty Ltd. ACN 104 037 372 +613 7067 6940 info@cynata.com Level 3, 100 Cubitt Street, Cremorne, Victoria 3121 ASX: CYP Cynata Therapeutics Limited ABN – 98 104 037 372 Level 3, 100 Cubitt Street Cremorne VIC 3121 Australia T: +613 7067 6940 E: info@cynata.com www.cynata.com 20 October 2026 Dear Shareholder IMPORTANT NOTICE Cynata Therapeutics Limited Unmarketable Parcel Share Sale Facility Cynata Therapeutics Limited (Cynata or the Company) is pleased to provide you with the opportunity to sell your shareholding without incurring brokerage or handling costs through an unmarketable parcel share sale facility (Facility). This Facility is open to shareholders who at market close on 19 October 2026 (Record Date) held fully paid ordinary shares in Cynata (Shares) with a value of less than $500 (Unmarketable Parcel), based on the closing price of $0.01 on the Record Date (i.e., holders of 49,999 ordinary shares or less). The Facility is being conducted to enable the Company to substantially reduce the administrative cost of managing small shareholdings and to provide investors with small holdings an opportunity to dispose of their holdings in the Company in a cost-effective manner. The Company will bear all costs, including brokerage related to sales under the Facility (although any tax consequences from the sale of your shares will be your responsibility). Our records show that at the Record Date you held an Unmarketable Parcel and are therefore eligible to participate in this Facility. Unless you advise the Company that you DO NOT wish to sell your Shares by 7.00pm Melbourne time on Monday, 7 December 2026 (Closing Date), the Company intends to sell your Shares through the Facility in accordance with rule 5.4 of the Company’s Constitution and the ASX Listing Rules. Payment will be sent to you following settlement of the sale or otherwise as soon as practicable. Shares sold under the Facility will be sold at a price of $0.01 per share (Facility Price), which is the same price as Shares are being offered under the Company’s recently announced Entitlement Offer. There is no guarantee that some or all of the Shares will be sold under the Facility and any unsold Shares will be retained by shareholders. Caravel Securities Pty Ltd ACN 665 357 915 (Carasec) has been appointed as broker to seek to sell the Shares sold under the Facility. The Shares will be placed as a single pooled parcel and each participating holder will receive the same Facility Price per share, with no deduction for brokerage or handling costs. The Company reserves the right to change any of the dates referred to in this letter or the enclosed Share Retention Form, or to vary, cancel or delay the Facility at any time before the Shares are sold, by making an announcement to ASX. If a takeover bid for Cynata is announced after the date of this notice but before an agreement is entered into for the sale of Shares under the Facility, those Shares will not be sold in the Facility. What do I need to do? You can choose whether or not to participate in the Facility prior to the Closing Date of 7.00pm Melbourne time on Monday, 7 December 2026. 1. Sell your shareholding via the Facility (DO NOTHING) If you do nothing, your Unmarketable Parcel will be pooled with other Unmarketable Parcels which are to be sold under the Facility and will be sold as soon as practicable after the Closing Date. Proceeds will be remitted to you as soon as practicable thereafter via direct credit to your nominated bank account. By refraining from taking any action on, or before the Closing Date, you will be deemed to have irrevocably appointed the Company as your agent under rule 5.4(c) of the Company’s Constitution: a) to sell your Unmarketable Parcel at the Facility Price without any cost being incurred by you; and b) to effect a transfer of your Unmarketable Parcel on your behalf and deal with the proceeds of the sale as set out below. If your Unmarketable Parcel is held in a CHESS Holding and those Shares remain in a CHESS Holding after the Closing Date, the Company may, without further notice, move those Shares from the CHESS Holding for the purposes of divestment by the Company in accordance with the Facility. The proceeds of the sale of Shares under the Facility will be distributed in accordance with rule 3.8 of the Company’s Constitution, and in particular rule 3.8(f) of the Constitution. The Board has discretion to deal with any unclaimed moneys under rule 3.8 of the Constitution. The proceeds of sale will not be applied in payment of the expenses of the sale. If your direct credit bank details require updating, you can amend your details online through Automic’s website at https://portal.automic.com.au/investor/home. This will ensure you receive your funds via direct credit in a timely manner. 2. Retain your holding (COMPLETE AND RETURN SHARE RETENTION FORM OR RETAIN ONLINE) If you wish to be exempt from the Facility and retain your existing Unmarketable Parcel of Shares you must sign and return the enclosed Share Retention Form or submit your retention online through Automic’s website at https://portal.automic.com.au/investor/home so that it is received by the Company’s share registry, Automic, by no later than 7.00pm Melbourne time on Monday, 7 December 2026. If your shareholding is worth at least A$500 on the Closing Date, whether by purchase of additional Shares by you or as a result of an increase in the market price of Shares or otherwise, your Shares will not be sold under the Facility. 3. A summary of key dates in relation to the Facility is as follows Event Date Unmarketable Parcels Record Date Monday, 19 October 2026 Unmarketable Parcels Announcement to ASX Tuesday, 20 October 2026 Letters sent to shareholders holding Unmarketable Parcels Friday, 23 October 2026 Closing Date for receipt of Share Retention Form Monday, 7 December 2026 Sale of Shares and payment of proceeds Late December 2026 IMPORTANT NOTES The attached Information Sheet with Frequently Asked Questions, which forms part of this document, sets out further details on the Facility. Please read this sheet before making any decision. Cynata and Automic do not make any recommendations or give any advice to you as to whether you should participate in the Facility. Information on the market price of Cynata shares is available from the ASX website (www.asx.com.au) under ASX Code “CYP”. If you have any questions regarding the Facility, please contact the Company on +61 3 7067 6940. If you require assistance regarding your shareholding, please contact Automic Share Registry at 1300 288 664 (within Australia), +61 2 9698 5414 (from outside Australia) between 8:30am to 7:00pm (Melbourne time) during business days or email corporate.actions@automicgroup.com.au. INFORMATION SHEET UNMARKETABLE PARCEL SHARE SALE FACILITY FREQUENTLY ASKED QUESTIONS 1. What is the Facility? Cynata has established the Facility to facilitate shareholders holding Unmarketable Parcels in Cynata to sell their shares. Cynata will arrange to sell the Unmarketable Parcels at no cost to you, and to remit payment to you. 2. Why is the Facility being offered? Cynata has established the Facility to enable you to sell your shares cost effectively and simply, while also assisting Cynata to reduce administrative and registry costs associated with servicing Unmarketable Parcels. 3. Does Cynata have the right to sell my shares? Under rule 5.4 of the Company’s Constitution, Cynata may notify shareholders who hold Unmarketable Parcels that it intends to arrange for their shares to be sold on their behalf. This letter and the Share Retention Form satisfy the notice requirements in rule 5.4(b) of the Company's Constitution. MY ELIGIBILITY 4. What is an Unmarketable Parcel? An "Unmarketable Parcel" is a holding of Cynata shares with a value less than A$500. Based on the closing price of Cynata shares of $0.01 on Monday, 19 October 2026, this is a holding of 49,999 shares or less. 5. What if the value of my holding increases before the Facility Closing Date? Cynata will not sell your Cynata shares if the market value of the shares increases such that you no longer have an Unmarketable Parcel on the Facility Closing Date. 6. If I buy more Cynata shares before the Facility Closing Date, will it retain my holding? Cynata will not sell your shares if you increase your holding of Cynata shares prior to the Facility Closing Date, such that you no longer have an Unmarketable Parcel on that date. Any additional shares acquired must be registered by the Facility Closing Date under the same name and address and with the same holding number (SRN or HIN) as set out in the accompanying Share Retention Form. 7. What if I sell my Cynata shares before the Facility Closing Date? If you sell your shares in Cynata prior to the Facility Closing Date, no further action will be taken. MY PARTICIPATION 8. Do I need to do anything to participate in the Facility? No further action is required if you wish to participate in the Facility. Cynata will pay the brokerage and handling costs associated with your participation in the Facility. However, any taxation consequences arising from the sale of your shares will be your responsibility. 9. What do I have to do if I wish to retain my shares? Cynata will not sell your shares if you wish to retain your Unmarketable Parcel and you complete the Share Retention Form included and return it to Automic or submit your retention online through the Automic website https://portal.automic.com.au/investor/home. Your Share Retention Form or online retention must be received by Automic before 7.00pm Melbourne time on Monday, 7 December 2026 in order to be effective. If you hold shares in multiple shareholdings, some of which are Unmarketable Parcels, in order to retain your shares, you must submit a Share Retention Form for each Unmarketable Parcel or merge the shareholdings by contacting Automic. 10. Can I withdraw my Share Retention Form? You can only withdraw your Share Retention Form before the Facility Closing Date by sending a written request to Automic which details your name, address and holder number (SRN or HIN) and states that you would like to withdraw your Share Retention Form. Your request must be signed. If your holding is in more than one name, your request must be signed by all shareholders. Your written request must be received by Automic before the Facility Closing Date in order to be effective. 11. What if my shares are held in a CHESS holding? If your shares are in a CHESS holding and remain in a CHESS holding on Monday, 7 December 2026, your shares will be sold under the Facility and Cynata may, without notice to you, initiate a holding adjustment to move these shares to an issuer sponsored holding for the purposes of that sale. 12. How much will I receive for my shares? Shares sold under the Facility will be sold at a price of $0.01 per share (Facility Price), consistent with the offer price of shares under the Company’s recently announced Entitlement Offer. All participating shareholders will receive the same Facility Price per share, with no deduction for brokerage or handling costs. Cynata does not give any assurance that any or all Unmarketable Parcels will be sold under the Facility, or as to the timing of any sale. If the Facility Price changes, the Company will announce this to ASX. Information on the market price of Cynata shares is available from the ASX website (www.asx.com.au) under ASX Code “CYP". Shareholders using the Facility are not able to nominate a sale price, sale date, nor a method for selling their shares. However, shareholders can opt out of the Facility by submitting a Share Retention Form and can choose to hold or sell their shares by other means. For instance, you can sell your shares on the ASX by contacting a broker. 13. How and when will the proceeds for the sale be sent to me? The proceeds will be sent to you as soon as practicable. The proceeds will be paid via a direct credit to your bank account at an Australian financial institution (where the Company has your details or upon nomination by you of a relevant bank account). You can update your bank account details by the Closing Date by login in to the Automic Investor Portal at https://portal.automic.com.au/investor/home. This also applies if you are an issuer sponsored shareholder and need to update your address. If you have a CHESS sponsored holding and need to update your address, you will need to contact your controlling participant. If you do not have an Automic login, you can register for an account at https://portal.automic.com.au/investor/home or contact Automic to request a physical form to update your bank details. Payment will be made in Australian dollars where an Australian bank account is nominated. Shareholders who hold Unmarketable Parcels who would like to receive their proceeds in a non- Australian bank account can update their bank details via the Automic Investor Portal. You will be notified of the number of your shares that have been sold, the sale price and the total sale proceeds payable to you. A statement will be sent by email or post to your address as shown in Cynata’s register of members as soon as practicable following settlement of the Facility. FURTHER INFORMATION If you require further information, please contact the Company on +613 7067 6940 or Automic Share Registry at 1300 228 664 (within Australia), +61 2 9698 5414 (from outside Australia) between 8:30am to 7:00pm (Melbourne time) during business days or email corporate.actions@automicgroup.com.au.